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Using the optimized annotations, Kendall's W was 0.384.
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The OGS was obtained by annotating the SSB draft genome using the Optimized Maker-based Insect Genome Annotation (OMIGA) pipeline (13).
Tests were made using the (optimized) log of SPL and a non-optimized log.
RESP (restraint electrostatic potential) atomic charges were derived for all ligands using the optimized geometries.
MRI images were analyzed using the optimized approach of VBM developed by Good et al., [33].
Enrichment replication was analyzed using Kendall's coefficient of concordance on the enrichment results computed using optimized annotations over multiple bootstrap resampled datasets, where these bootstrap datasets used to compute concordance were distinct from the bootstrap datasets used during annotation optimization.
Create the optimized annotation matrix by setting.
An optimized version of the C2 gene sets, representing matrix T, was generated by filtering the optimized annotation matrix O at a threshold of 0.1.
An optimized version of the cancer modules, representing matrix T, was generated by filtering the optimized annotation matrix O at a threshold of 0.15.
Using optimized annotations, Kendall's W was 0.507.
In the simulation example outlined in Section 3.1, such a relationship between variable group enrichment and inter-variable correlation was explicitly created for the first five variables in the first two variable groups with the predictable result that these variables were not filtered by EMVC and significantly lower enrichment FDR values were obtained using optimized annotations.
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