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Fig. 4 Typical chromatogram of the purified and formulated [11C]erlotinib using the optimized analytical HPLC (top: UV-channel; bottom: radioactivity-channel).
The entire quality control process (except for tests for residual solvents, endotoxins and sterility) was completed within 3 min using the optimized analytical HPLC system.
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Reextract the spectrum using the optimized (EEFRAC=78%) extraction region.
Tests were made using the (optimized) log of SPL and a non-optimized log.
A verification experiment using the optimized medium was carried out.
Using the optimized annotations, Kendall's W was 0.384.
The optimized analytical method for HPLC was a multi-step gradient elution using acetonitrile and water.
The optimized analytical method for ultra fast high performance liquid chromatography (UFLC) was a gradient elution using water containing 0.04‰ formic acid (A) and methanol containing 0.04‰ formic acid (B), at a flow rate of 0.3 mL/min.
The supernatants are analyzed under the optimized analytical condition (Tables 3 and 4).
We conclude that the outcome of EEG-fMRI can be improved by using an optimized analytical strategy, but also depends on the number of IEDs occurring during the recording.
The initial guesses for the FOPID controller parameters to be optimized are found using the analytical solution for integral squared error optimization for an integer order PID controller.
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