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After adjustment for trend using the null sequence ratio relative bias was reduced to 1% or less.
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In all simulations adjustment for trends in prescribing using the null-effect sequence ratio appeared to effectively overcome under-ascertainment bias.
However, correcting for the GC content sequence biases using the null probes eliminated this autocorrelation, allowing us to assume independence in signals arising from consecutive null probes.
Concertina was removed using the null allele [13].
We denote the set of sequences of length as and the null sequence set by. Finally, we denote the set of all sequences by.
The methods all use the null space and associated null vectors of the structural stiffness matrix.
Draw squares using the Fibonacci sequence.
We generated these expectations by simulating data under the null model (e.g., the phylogeny estimated with the molecular clock enforced) using the model of sequence evolution appropriate for our empirical data.
However, using the appropriate null model, we found a significant enrichment of plasticity in natural sequences.
We have previously reported the development of very high resolution (VHR) HLA genotyping, designed to resolve the majority of both the "common and well documented alleles" and the null alleles using the 454 GS FLX Sequencing System and Conexio genotyping software.
We generated artificial alignments by simulating sequence evolution along the tree of the original sequences using the parameters of the null models (in the absence of positive selection) for all genes.
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