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Such analysis of the relationship between a daughter cell's "encounter histories" and its subsequent fate choice can be performed using the new transgenic mouse lines we describe here.
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Therefore, it may be worthwhile revisiting some of these experiments (especially those involve cAMP pathway or cytokine signaling) using the new-generation cre transgenics such as the 'self-excising cre' or using the ROSA-Cre system where CRE-ERT2 is integrated at the rosa26 locus, which eliminates random integration effects and the effect on the PKA pathway by regulated administration of 4-OHT.
We have used the new humanized double-transgenic model of arthritis to test oral administration of the altered peptide ligand A12 peptide and to demonstrate that T cells found in the GALT tissues release IL-10 and IL-4 in response to a murine autoantigen [ 17].
In the first point, the reviewers ask for further description of the new transgenic mice used in this study.
"Everyone knows transgenic soybeans have been smuggled in from Argentina," he said, and the pressure to use the new technology, legally or not, is intense.
Use the new design.
Use the new number.
Use the new printing tools.
Use the new SIM card.
Glucose uptake into L cells (either GLUTag cells or cells in primary cultures, using a new transgenic mouse model combining proglucagon promoter-driven Cre recombinase with a ROSA26tdRFP reporter) was monitored with the FLII12Pglu-700μδ6 glucosensorsensor
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