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The newly designed compounds were synthesized on the trails of ketoconazole using the molecular hybridization approach.
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To address this issue, we report herein the synthesis of N- 4-oxo-2 substituted thiazolidiN- 4-oxo-2aziN- 4-oxo-2hydrazide derivatives desigN- 4-oxo-2lowing the molecular hybridization approach usubstitutedne and thiazolidenone scaffolds.
Moreover, a recent study in asthma has used the molecular techniques of in situ hybridization and immunohistochemistry to localize cells that express either the mRNA or the protein for the cysLT1 receptor, respectively [ 35].
A novel series of etravirine VRX-480773 hybrids wetravirine VRX-480773ructure-guided molecular hybridszation strategy and fusing the pharmacophore templates of etravirine and VRX-480773.
In this study we describe the rationale design for synthesis using molecular hybridization and subsequent in-vitro antimycobacterial activity of various indolo-pyridone hybrid molecules against Mycobacterium tuberculosis H37Rv.
Using molecular hybridization and subtraction techniques, the SSH cDNA library approach reduces the cloning of abundantly expressed housekeeping genes or genes commonly expressed in both control and treated plants, thereby normalizing expressed cDNA profiles during library construction.
In 1992, Tchurikov et al. showed that parallel complementary probes of normal nucleotide consisting of both AT/GC base pairs can be used for molecular hybridization experiments, indicating the stability of G-C containing parallel DNA.
Thus, a novel series of DAPY-IAS hybrid derivatives were identified as newer NNRTIs using structure-based molecular hybridization.
A series of cinnamide derivatives was designed as potential antimycobacterial agents using molecular hybridization approach.
A series of 1,2,4-triazole-based compounds was designed as potential antibacterial agents using molecular hybridization approach.
In the present study, we have designed a series of (1-phenyl-9H-pyrido [3,4-b]indol-3-yl) (4-phenylpiperazin-1-yl)methanone derivatives using molecular hybridization approach.
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