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Study group allocation will be conducted at individual level, using the minimisation technique.
Patients returning these documents were randomised 1 : 1 by an independent secretary using the minimisation technique 21 and the SiMin software.
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Through a minimisation software, the eligible patients will be allocated using the minimisation method with a preset variable the presence of syringomyelia.
Randomisation will be conducted independently (and after the baseline interview) by a statistician, using the minimisation method [ 23].
In the specialized care trial the minimisation technique will be used to force treatment allocation of individual participants with consideration of the prognostic factors age (6 8 years old and 9 11 years old) and level of asthma control (ACQ score <1 and ACQ score ≥ 1).
The minimisation technique [ 89] will be used to allocate the patients into one of two groups (i) lifestyle intervention group, incorporating moderate dietary energy restriction of 600 kcal per day in conjunction with aerobic exercise training on 3 5 days per week, or (ii) normal care control group.
We will use the minimisation method for randomisation to assure an equal distribution of baseline characteristics.
Practices were randomly assigned to either arm of the trial using a minimisation technique (Pocock, 1983) to ensure that the two groups were balanced for size of practice, historical referral rate to cancer genetics services and social deprivation index.
Practices were randomly assigned to either arm of the trial using a minimisation technique (Pocock, 1983, pp 84 86) to ensure that the two groups were balanced for: size of practice; historical referral rate; and social deprivation index.
Randomisation was done centrally at the EORTC headquarters, Belgium, using a minimisation technique.
Using a minimisation technique to randomise patients, the two groups were well balanced for T-stage, lymph node involvement, oestrogen receptor (ER) status, neoadjuvant systemic treatment plan and CT type (anthracycline/taxane), menopausal status, the use of statins (which also act on the mevalonate pathway) and treatment centre.
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