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Randomisation will be conducted independently (and after the baseline interview) by a statistician, using the minimisation method [ 23].
The study was stratified for individual trial, tumour type, age and sex using the minimisation method, which was implemented in the CTU's Oracle database.
Through a minimisation software, the eligible patients will be allocated using the minimisation method with a preset variable the presence of syringomyelia.
Having allocated the patient to a hygienist, the patient was then allocated to either intervention or control group using the minimisation method (with weighted randomisation) [ 14, 15].
Patients were randomly assigned at a 1 : 1 ratio to either the gemcitabine group or the surgery-only group using the minimisation method stratified by resection status (R0 versus R1), pathological stage (I II versus III IV) and enrollment centre.
Randomisation was performed centrally, with assignment for pathological T and N stage balanced using the minimisation method with probability and the method of Zelen (Yonekura et al, 1999; Tanaka et al, 2002).
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We will use the minimisation method for randomisation to assure an equal distribution of baseline characteristics.
The randomisation used the minimisation method [ 18] to give an equal balance between groups of the following: gender, age, date of diagnosis, and whether patients could or could not communicate.
Study group allocation will be conducted at individual level, using the minimisation technique.
Randomisation was done using stratified randomisation, in particular the minimisation method.
Randomisation took place using stratified randomisation, in particular the minimisation method described by Pocock [ 19].
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