Mice were analyzed for airway hyperresponsiveness using the mechanical ventilator apparatus in response to PBS or increasing doses of aerosolized methacholine from 1 mg/mL to 100 mg/mL as described [29], [36], [37].
Also, as already stated, a standard airway pressure profile throughout the respiratory cycle, as would be the case when using the mechanical ventilator of the anaesthesia machine in pressure control mode, was not provided.
We used the mechanical ventilator Adult Star (Infrasonic, Inc., San Diego USA).
Pulmonary function was measured invasively in a subset of rats 7 days after treatment with DA (n = 8) or vehicle (n = 4) using the FlexiVent mechanical ventilator and data acquisition system (SCIREQ, Montreal, PQ, Canada).
AHR was analyzed using the FlexiVent mechanical ventilator system (Scireq; Montreal, Quebec, Canada) as previously described (Wilson et al. 2009).
Traditional approaches to mechanical ventilatory support of patients with acute respiratory distress syndrome require adaptation of the patient to the mechanical ventilator using heavy sedation and even muscle relaxation.
These mechanics have been use in a mathematical model and proven useful for evaluating the mechanical ventilator treatment [ 15, 16].
After inclusion in the study, all patients were sedated and paralysed with a continuous intravenous infusion of fentanyl 250 μg/h, flunitrazepam 1 mg/h and vecuronium 4 mg/h, and their lungs were ventilated using conventional mechanical ventilation (César Ventilator, Taema, France).
Nebulizers are used for medication or humidification of air, and inserted into the inspiratory phase of the mechanical ventilator circuit.
The aim of the present study was to gain insight into the mechanical ventilator adjustment process, particularly events that prompt clinicians to adjust the ventilator, the indications, considerations, and methods used to assess the successfulness of the adjustment episode.
After endotracheal intubation, dogs were maintained on controlled ventilation with 100% oxygen using a mechanical ventilator (Model SN-480-5; Shinano Manufacturing, Tokyo, Japan) Core body temperature was maintained at normothermia (38 ± 1°C) with an electric heater (Pig-heaterdan®, Tozai Co., Ltd, Japan) and body temperature was monitored with a temperature probe in the rectum.
