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This cross-validated AUC may be regarded as an estimation of the expected probability of two randomly chosen future ill or healthy subjects being correctly classified as ill or healthy, respectively, using the main regression model described above.

Unigrams features were used with SVM to classify the reviews for evaluation purposes, but not used in the main model.

To further illustrate the effects of individual parameters on model performance, we also plot the criterion values as a function of each of the three parameters while holding the other two parameters at set values used in the main model simulation (Fig. S2).

This subgroup analysis added the variables of pain, sleep, and prior depression treatment to those used in the main model to determine additional predictors of poor treatment outcome.

9 In addition, study participants with missing 25(OH D measurement, missing values for covariates used in the main model, or participants lost to follow-up due to unknown reasons were excluded.

The covariates used in the main model were: randomisation to intervention group (iv = 1), time of observation (baseline BL1, BL2 and BL3 (reference) and T6 and T12 i.e. 6 and 12 months after start of reminiscence) and interaction variables T6*iv and T12*iv.

Odds ratio (OR) with 99% confidence interval (CI) and model fit (c-statistic and R ) were calculated per diagnosis group and per age group using the main multivariate logistic regression model.

For the assumed scenario of a compacted clay cover, the non-hysteretic model using the main drying SWCC leads to significantly different results than the hysteretic model, further demonstrating the necessity of accounting for hysteresis in unsaturated seepage analysis.

We employed a fully crossed factorial model using the main effects of Strain and Sex.

We repeated both risk and outcome analyses while stratifying on calendar time periods, comorbidity levels, age groups, and medical indication for statin use in the main model (1997-2009).

The Yamoto, Choshi, Miyako, and Minase stations [(a)–(d) in Fig. 1] were used for the main modelling for two reasons.

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