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Guidelines recommend using the lowest effective dose of oestrogen for the management of vasomotor symptoms in postmenopausal women.
Risks associated with hypertension can be minimized by using the lowest effective EPO dose, which may be achieved through the regular use of i.v. iron.
Using the lowest effective dose for the shortest period of time minimizes the risks to the unborn child.
Risk of bleeding should be minimized by using the lowest effective dose among short-term and long-term aspirin users.
These data suggests that minimization of bleeding risk should focus on using the lowest effective dose for both short-term and long-term users.
The clinical management guidelines published in 2014 recommend using the lowest effective dose for the shortest duration for management of menopausal symptoms [ 57].
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"Until we have that information, women who use any of these products should work with their doctors to use the lowest effective dose for the shortest duration of time".
That is why we decided to use the lowest effective dose: 25 ng/ml, in following experiments.
Clinicians should balance the risks and benefits of chronic PPI therapy in older patients and use the lowest effective dose when possible (see Table 2).
Morison and Morison [ 33] advise when ever possible to use the lowest effective dose of opioid medication and titrate the bowel regimen accordingly.
This therapy included combination of low-dose glucocorticoids and either cyclophosphamide (up to 1.5 mg/kg/day), azathioprine (up to 2 mg/kg body weight) or methothrexate (up to 20 25 mg/kg body weight/week) with the goal to use the lowest effective dose and replace cyclophosphamide with azathioprine or methothrexate, if possible [ 12, 19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com