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Using the logical model, we simulated the induction of the signal transduction in response to combined radio- and chemotherapy caused by ionizing radiation (equation 1) and VP16 (equation 4).
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Another goal of this study was to use the logical model to generate in silico predictions and to verify these experimentally.
We then used the logical model to compute the response of the network (i) when the network is triggered with HGF and (ii) when c-Met is stimulated by H. pylori, both for the early events (connection 52 is off).
For this example we mapped the logical model to a data model using the caAdapter graphical tool.
Since in the logical model, only one discrete value is used as an abstraction for the concentrations of c-di-GMP that are considered as the on-state, this negative feedback inhibition has no observable logical effect.
Physical level is used to choose a target database management system (DBMS) for implementing the logical model.
Dynamical analyses of the logical model were performed with GINsim.
ATP t = Ca t + 1 ≡ NOT Ca t AND Bile t OR NOT 2 ATP t = Ca t + 1 We use knowledge assembled in the logical models [ 22] and [ 23] for the construction of our network.
This chapter is designed to review the logical models and query languages used in spatial database systems.
In recent years the logical models based on ontologies spread.
The logical modelling framework is described in the Methods section.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com