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Hence, the error rate in SNP discovery was 49.0% (2,655 false positive SNPs of 5,420 SNPs) using the initial SNP filtering criteria (Table 2).
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Because there was only one Group V used in the initial SNP discovery and only a small number of Group V accessions was included in this study (n = 14), we were unable to obtain reliable results for this subpopulation, and focus instead on documenting admixture between indica, tropical japonica, and temperate japonica.
Three SNPs (rs34037914, rs169068, and rs642249) were significantly associated with the presence of acromegaly using the initial controls.
In the initial SNP selection process, we used another 16 Japanese samples which are recruited in the Fukuoka area and informed in the same way.
The initial SNP analysis identified 17 candidate SNPs among the 3 transplant isolates.
Note that the choice of the 400 SNPs was arbitrary, but it roughly represents 10% of the initial SNPs.
Using the same 100 SNP windows, we calculated π and d.
a Distribution of 260 informative SNPs across 12 rice chromosomes detected using the 384-SNP assay (OPA 6.1) (left) and 1868 polymorphic SNPs using the C6AIR (right).
To replicate our initial results, we next genotyped 1080 European-derived independent SLE patients and 1080 healthy unrelated controls matched for sex and race using the same 21 SNPs in the MECP2 region (Table 1).
Initial haplotype analysis was conducted using the dense single nucleotide polymorphism (SNP) map from Perlegen Inc. (Mountain View, CA) (≈8.3 million SNPs).
To identify the independent effect of other SNPs in the region of the most significant SNP, the likelihood ratio test was again used in the initial GWAS sample with the most significant SNP and those covariates involved in the basic model.
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