Estimates of apparent oral clearance (Cl/F) and area under the plasma concentration vs. time curve at steady state (AUC) were derived using the individual parameter estimates.
Here we predicted the treatment outcome in a patient using the individual parameter estimates, which are the modes of a posteriori distribution, and therefore defining a yes/no response.
A sequential model building approach, using the individual pharmacokinetic parameters method was used to develop the pharmacokinetic models for gemcitabine and its metabolites (Zhang et al, 2003).
Using the individual model-parameter relative entropies as a measure of resolution, one can make quantitative judgments about which part of the history is likely to be well resolved.
The individual-level WTP is calculated according to Equation 8 using the individual-level parameters for the non-price attributes, respondent characteristics, and the fixed parameters on these characteristics, along with the fixed parameter on price.
From the discussion in Section 2.2, we can deduce that not using the individual optimum p parameter (4) for the schemes proposed in Section 3 might lead to some performance degradation.
The neurobiological significance of these metrics remains relatively little explored: whilst fractional anisotropy (FA) has been the most widely cited metric, more recent studies have suggested that use of the individual parameters of diffusion may be more appropriate in neurodegeneration [Acosta-Cabronero et al., 2010; Mahoney et al., 2013].
The tool now uses the individual model parameters to suggest a tailored maintenance dose.
The tool then uses the individual model parameters in the next step, which can be either dose estimation or INR prediction.
One hundred simulations of CA-125 and tumour size profiles from the learning data set were performed using the final individual parameters estimated from the model.
