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Linkage disequilibrium (LD) was assessed using the Haploview software [28].
LD statistics were calculated and haplotype blocks were visualized by using the Haploview software [42].
Pair-wise LD was measured by r2 for all SNPs less than 100 kb apart using the Haploview software [31].
Haplotype structure was analyzed using the Haploview software, and haplotype blocks were defined through confidence intervals (default).
In addition, the linkage disequilibria (LD) structure of the identified contiguous SNPs was examined using the HAPLOVIEW software [33].
The significance of the SNP alleles was determined using the Haploview software package (version 4.1; http://www.broad.mit.edu/personal/jcbarret/haplo/).edu/personal/jcbarret/haplo/
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We used the Haploview software (http://www.broadinstitute.org/haploview/) to infer the LD structures in regions containing loci associated with insomnia risk.
The Hardy-Weinberg equilibrium (HWE) was tested using the Haploview 4.1 software (Daly Lab at the Broad Institute, Cambridge, MA, USA).
Intermarker LD was visualized and pairwise R values were determined using the Haploview v3.2 software (Barrett et al. 2005).
Subsequently, genotyped tag SNPs among the candidate tag SNPs were determined based on linkage disequilibrium (LD) tagging using the Haploview 4.1 software program (r > 0.8) [ 20].
The levels of linkage disequilibrium were estimated using the r parameter between all pairwise comparisons using the Haploview 4.2 software (Barrett et al. 2005) and a minor allele frequency (MAF) cutoff of 0.01.
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