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Instead, we performed a narrative summary of outcomes presented in the included study and assessed the strength of the evidence for each outcome using the GRADE version 3.6 (grading of recommendations, assessment, development and evaluation) approach to reviewing evidence [ 40].
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A first version of recommendations was elaborated using the GRADE method (Grade of Recommendation, Assessment, Development and Evaluation) [ 7, 8].
Adverse events were graded using the National Cancer Institute Common Toxicity Criteria version 3.0.
All toxicity was graded using the National Cancer Institute Common Toxicity Criteria version 2.0.
The incidence and severity of adverse events were graded using the National Cancer Institute Common Toxicity Criteria version 4.0.
Adverse events and toxicity were graded using the National Cancer Institute Common Toxicity Criteria version 2.0 (National Cancer Institute).
Toxicity was graded using the National Cancer Institute Common Toxicity Criteria, version 2.0 (NCI-CTC v2.0).
Toxicity was assessed weekly and graded using the National Cancer Institute Common Toxicity Criteria CTCAEE) version 3.0.
Toxicity was graded using the National Cancer Institute Common Toxicity Criteria version 3.0 (NCI-CTCAE v3.0).
Adverse events were evaluated and graded using the National Cancer Institute Common Toxicity Criteria, version 3.0., until 30 June 2011, and version 4.0 thereafter.
Toxicities were evaluated at least weekly during the study period and graded using the National Cancer Institute-CTCAE version 3.0.
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