Following the grading of the evidence for each of the seven PICO questions, seven separate SoF tables were developed by the first author using the GRADE-Pro software.
The same reviewer assessed the full text articles and determined that 14 of the 26 offered quantitative results that could be analyzed using the GRADE-pro software [ 28- 41].
50 The robustness of evidence will be assessed by using the GRADE classification 64 77 and its software GRADEpro.
We graded the quality of evidence for the primary outcome using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach 21 22 using GRADEpro software V.3.6 (for Windows; Jan Brozek, Andrew Oxman, Holger Schünemann, 2008).
19 We evaluated the quality of the body of evidence for individual outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system 21 and GRADEpro software.
20 We graded the quality of evidence for the three main outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach 21 with GRADEpro software (version 3.2 for Windows. Jan Brozek, Andrew Oxman, Holger Schünemann, 2008).
We used the GRADE system and its quality of evidence criteria as well as GRADE-Pro software to analyze the articles for each PICO question.
The Wilcoxon test for nominal variables (grades of reduction of microvilli) was performed using the "R" software on Linux Ubuntu 14.04.
Data were graphed using the Prism software.
Data were analyzed using the instrument software.
