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50 The robustness of evidence will be assessed by using the GRADE classification 64 77 and its software GRADEpro.
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Another morphological-based criterium, better tumour differentiation grade using the grading system outlined by the WHO classification of tumours Sobin et al. (2010), highly correlated with post-treatment down-categorisation from cT3 to ypT0 T2 in our cohort.
The grade classification model uses significant sustainability development criteria such as: economic; social; and environmental criteria.
All cases of IPMN and MCN were subclassified based on the grade of dysplasia: low-grade, intermediate-grade, and high-grade, using the WHO classification [ 17].
Blindness and visual impairment was defined as presenting VA <3/60 and <6/18 to 6/60 in the better eye respectively and DR was graded using the International classification of Diabetic Retinopathy severity grading scale.
Diabetic retinopathy (DR) was graded using the International classification of Diabetic Retinopathy severity grading scale [ 11] as No DR, Mild non proliferative DR (mild NPDR), Moderate non proliferative DR (moderate NPDR), Severe Non Proliferative DR (NPDR), Proliferative diabetic retinopathy (PDR) and Macular edema.
Cartilage abnormalities were graded using the Noyes classification system [11].
Pin-site infections were graded using the Otterburn classification [31] (Table 1).
The severity of degenerative knee changes was graded using the Ahlbäck classification [ 24].
Notches were classified into 4 grades using the Tayside classification as follows.
Ulcers were graded using the Wagner classification system and ulcer areas were measured using Visitrak Digital (Smith & Nephew, Hull, England) (20).
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