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The retrieved evidence will be assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach.
We assessed the quality of evidence for the outcomes of the included studies using the GRADE approach (GRADE 2008).
A first version of recommendations was elaborated using the GRADE method (Grade of Recommendation, Assessment, Development and Evaluation) [ 7, 8].
Quality of evidence was graded using the GRADE approach.
Certainty of evidence was assessed using the GRADE methodology.
Risk of bias was assessed using the GRADE guidelines [25].
Trial quality was assessed using the GRADE system.
These judgements are made using the GRADE system, and are provided for each outcome.
Randomized controlled trials were assessed for quality of evidence using the GRADE system.
However, the overall quality of evidence was rather limited and rated 'low,' using the GRADE approach.
Literature analysis and formulation of recommendations were then performed using the GRADE system (Grade of Recommendation Assessment, Development and Evaluation) [4, 5].
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