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Design Cohort study using the general practice research database.
Baseline variables were derived using the general practice data (see codes in Additional file 1).
Prescriptions issued by doctors using the general practice research database are automatically transcribed into the computer record.
A cohort study 9 in patients aged 18 to 89 using the general practice research database found that venlafaxine use was associated with a higher risk of suicide and attempted suicide than was citalopram, fluoxetine, and dothiepin.
In recent years, there has been a research-based focus on using the general practice setting for health promotion including improving dietary and exercise practices among patients, particularly for weight management.
The authors concluded that this could reflect residual confounding since they found that venlafaxine users had a higher burden of risk factors for suicide, as was also the case in a previous study using the general practice research database.
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This study used the general practice research database and involved 100 000 statin users followed for under three years.
Previously we used the general practice research database to study the incidence of cancers in patients presenting in primary care with four "alarm symptoms"—haematuria, dysphagia, haemoptysis, and rectal bleeding.
The current study is a cluster randomised design, using general practices as the unit of randomisation.
This risk equation was chosen as it can be incorporated within Vision, the electronic system used by general practices that contribute to the THIN database.
30 31 THIN contains anonymised patient data directly extracted from practices using the Vision general practice system.
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