The primary end point was safety, which was assessed through the reporting of adverse events using the Division of AIDS (December 2004) toxicity grading scale.
A renal toxicity management protocol was established for serum creatinine and phosphorus adverse events using the Division of AIDS (DAIDS) Adverse Event Grading Table [34] and has been described previously [1].
The assignment of the severity/grading of adverse events will be made by the investigator responsible for the care of the participant using the Division of AIDS Table for Grading the Severity of Adult and Paediatric Adverse Events V.1.0 (2009) definitions.
For this article, we have not used the division of EPEC into EPEC 1 and EPEC 2, but it may be important in the future.
We did not use the division of sequences into known isochore families [ 68, 69], but we did use the same "borderline" GC content values for separating and designating the obtained GC groups by the isochore family names: L1: GC content < 37%, L2: 37 42%, H1: 42 47%, H2: 47–52%, and H3: GC content >52%.
Thus, according to [ 19], we used the division of 20 amino acids into three groups by the degree of hydrophobicity, including hydrophobic (C, F, I, L, M, V, and W, seven in total), hydrophilic (D, E, G, K, N, P, Q, R, S, and T, ten in total), and neutral (A, H, and Y, three in total).
Indeed, if we take the frequency of CC production from SecCs as the lowest 95% confidence interval from our EdU measurements (7% of all SecC divisions) and use the division rate of SecCs from our model, we find that less than 1% of CC production can potentially originate from BLPs (Supplemental Theory).
For example the peptide (AIRHIPRRIR) is mapped into (2312321131) using the hydrophobicity division of amino acids into three groups (see Table 20).
Because of that data limitation, we use the divisions and subdivisions of the North American Land Mammal Ages (NALMAs) [30], [34].
In this way, an equitable principle (one third) is used for the division of the database in three data sets.
Surface grinding is a familiar method used in the division of manufacturing in order to generate smooth finish on flat surface.
