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A gene ontology (GO) analysis was performed using the DAVID website.
Gene lists were tested for over-represented GO terms using the DAVID website.
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For the second, we used the DAVID website to identify Gene Ontology terms that were enriched in the list.
The analysis of functional gene annotations was performed using the DAVID ver. 6.7 available on website [ 35, 72].
The biological themes were further analysed using the DAVID database [ 31, 32] (with the appropriate background gene list selected for the make of microarray at the website).
Significance was calculated using the DAVID 6.8 Functional Annotation Tool with the GO biological process direct database (https://david.ncifcrf.gov/ 58,59.ncifcrf.gov/ 58,59
Differentially expressed genes were categorized in GeneOntology groups using the DAVID tool (http://david.abcc.ncifcrf.gov/).abcc.ncifcrf.gov/
Functional clustering was performed using the DAVID database.
We analyzed the 1,817 genes that were hypermethylated only in RL cells using the DAVID interface (http://david.abcc.ncifcrf.gov/).abcc.ncifcrf.gov/
Functional annotation and enrichment analyses were done using the DAVID platform version 6.7 (http://david.abcc.ncifcrf.gov/home.jsp) [36], [37].
KEGG pathway enrichment analysis was performed using the DAVID web server (http://david.abcc.ncifcrf.gov/home.jsp).jsp
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