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Here, the results for gA channel using the cycle flux calculation are demonstrated.
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How is the cycle flux evaluated?
The rate of cycle completion is called the cycle flux.
The cycle flux contains more detailed information than the net flux.
The cycle flux was calculated with the following procedure.
We refer this approach the cycle flux algebra.
For one-way cycles having multiple paths, the cycle flux was calculated as the sum of the cycle flux for the paths.
Each cycle κ with the cycle flux of Jκ is composed of two one-way cycles having directionality for outward flux (Jκ+) and inward flux (Jκ–), where Jκ = Jκ+– Jκ−.
The concept of the cycle flux is visualized in the following way (Fig. 1C,D).
Then, the cycle flux was calculated for the first time for the KcsA potassium channel.
The underlying theory of the cycle flux and the diagrammatic methos are presented.
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