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The LC configuration is theoretical, but tissues that are, for any reason, partially anoxic and/or hypercapnic can be detected using the corrected anion gap and the venoarterial carbon dioxide gradient of the blood.
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An even simpler formula – (Na+ + K+) - (Cl- + HCO3-) - 2.5 albumin [g/dl]) - lactate (mmol/l) – for the corrected anion gap without the use of phosphate can be used and retain a strong correlation with SIG (r2 = 0.93) [ 8, 28].
They thus demonstrated that the corrected anion gap could be used in place of the more cumbersome SIG.
While these differences are important in assessing chloride alone, they will also affect derived variables including the anion gap [ 26], the corrected anion gap [ 27], the strong ion gap [ 28], and the sodium chloride difference [ 29].
In keeping with previous studies [ 4, 5, 13], Moviat and colleagues found that while the uncorrected anion gap was of little value in detecting unmeasured ions, there was an excellent agreement between the SIG and the corrected anion gap.
It is wise to check that the corrected anion gap [ 30, 31] and perhaps the strong ion gap [ 32, 33] are also normal.
By substituting the corrected anion gap in place of the SIG, we found a strong correlation between the two (r2 = 0.96) [ 28].
The corrected anion gap was calculated as follows: ([Na+ + K+] - [Cl- + HCO3-]) - 2.0 albumin [g/dl]) - 0.5 phosphate [mg/dl]) - lactate (mEq/l) [ 8].
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