Sentence examples for using the conditional knockout from inspiring English sources

Furthermore, studies using the conditional knockout mice have revealed the specific functions of GAGs in individual organs.

In an elegant study elucidating the role of microRNAs in skin development this issue has been addressed using the conditional knockout of genes involved in different steps of miRNA processing displaying a phenotypic overlap [ 14, 15].

Using the conditional knockout mouse model of NPC1 disease described above, it was also shown that loss of NPC1, specifically from neurons, is sufficient to cause neurodegeneration and to recapitulate neurological signs of the disease (Fig. 2B) (Elrick et al., 2010; Yu et al., 2011).

We investigated the role of the Rac1 GTPase in these processes by targeted deletion of expression using the conditional gene knockout (cKO) approach.

More specifically, the second stage of the multi-purpose allele after recombinase conversion could be used for the conditional knockout of PTBP1 in pancreatic β-cells only [45] in order to test the role of this gene in insulin granule biogenesis and diabetes [18], [19], [46].

We used the same conditional knockout line crossed to CreER and administered tamoxifen at E10.5.

In this study, we investigated the role of ADAR1 in the intestinal tract using a conditional knockout mouse model.

To study the role of miRNAs in the kidney several publications have addressed this question using a conditional knockout of Dicer, the RNAse III enzyme catalyzing the maturation from pre-miRNA to mature microRNAs [ 2- 9].

To overcome this problem, we extended our analysis in the inner ear using Neurod1 conditional knockout mice [Neurod1f/f,Tg(Pax2-cre)]. By generating the Neurod1 conditional knockout (CKO) mice we could successfully circumvent the effect of Neurod1 in pancreatic β-cell development and could rescue mice to adulthood in Mendelian ratio.

Indeed, data from our laboratory revealed a novel role for Myc in the mammary gland using a conditional knockout approach.

Using a conditional knockout of the histone cluster and a transgenic recovery system, they were able to investigate the importance of histones and their modifications and the role of histone variants in the fruit fly Drosophila melanogaster.