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The linearity of our method was confirmed using the classical tests by analysis of variance.
In-depth information about the molecular mechanisms is provided allowing a better understanding of molecular pathways activated by toxicity, which will not be possible when using the classical tests alone [ 5].
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Reproducibility (Kuder-Richardson 20 - KR-20) of the test was calculated using the classical test theory as provided in IDEAL 4.1, an Item Analysis Program [ 26].
So, the comparison between covariate effects on event 1 and event j can be directly tested by H0: β jk = 0 using the classical Wald test or the likelihood ratio (LR) test.
The a posteriori probability of success or failure of the 30-minute DSA test was calculated using Bayes' theorem, taking the extubation failure rate using the classical T-tube test method (14.5% in our centre, which is similar to that found in the present study) to be the a priori probability.
Only those SNPs that pass a threshold in the first step are examined for significant interaction effect using the classical likelihood ratio test that is computationally more expensive.
Drug sensitivity assays were done using the classical isotopic 48-h test, as described [12], on blood samples with parasitaemia ≥0.1%, available within 48 h after blood collection and from patients declaring no antimalarial drug intake during the previous 7 days.
The first pressure-transient prototype is tested using the classical sulphite oxidation reaction in the presence of cobaltous catalyst.
The estrogenicity of chlordecone, methoxychlor, and o, p′-DDT in doses relevant to the autoimmunity experiments was tested using the classical end point of uterine hypertrophy.
Furthermore the spatial pattern obtained by the ODT-model defines a potential clusters set which can then be tested using the classical Monte Carlo inference.
We hence tested, using the classical twin design, whether specific dimensional autistic traits, including social difficulties, communication atypicalities and repetitive behaviours, would display differential degrees of aetiological overlap with specific traits of ADHD, including hyperactivity/impulsivity and inattention.
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