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The disease progression in each patch (campus) is tracked using the baseline model, and the transmission among patches is represented by the mobility of (untraced, unquarantined and unisolated) individuals from one patch to another on a given dispersal network (see S1 Appendix C for details).
The variance explained was estimated using the baseline model and main model [ 31].
Repeat the experiment to determine median time-to-evolve per CRM using the baseline model as the fitness function, but targeting the merged expression pattern.
In all cases, observed P values fitted a uniform distribution better (curve closer to the diagonal) when using at least one of the alternative kernels than when using the baseline model of the published GWAS study [ 27] (Additional file 2: Figures S1, S2).
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Because the differences between the results of the analyses using the baseline models and the analyses using the extended models were small, we will only describe the results of the extended models.
All the specifications use the baseline model as specified in col. 4 of Table 1.
To this end, we used the baseline Model 1 with final probability P f = 1 (which was not rejected) and found the number of experiences x that gave the prescribed success rate.
The mismatch for prewire = 0.1293 is even stronger because changing the rewiring probability has a larger effect on SW in the case of large networks than for small networks – recall that prewire = 0.1293 was determined from N = 66, that is, in this case we used the baseline model of the smaller network to mimic the larger one.
Each counterfactual uses the baseline model but alters a single input.
We start by presenting results of the comparison of the approaches used for fitting the year effect, since with these we only used the baseline model.
Specifically, as noted in the section "Uniformly expressed activators can speed up emergence of CRMs," we take a D. melanogaster CRM, use the baseline model to predict its expression pattern (say " T"), and use this pattern as the target of a PEBCRES simulation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com