Sentence examples for using the amyloid hypothesis from inspiring English sources

The simultaneous development of gene technology and using the amyloid hypothesis led to the discovery of many mutations in other genes causing early-onset Alzheimer's disease.

If the proposed minimum Aβ lowering criterion is used, then the amyloid hypothesis has yet to be adequately tested in the clinic.

Whilst used as evidence for the amyloid hypothesis, these latter explanations for plaque accumulation also fit with the other plausible explanations for plaque accumulation outlined above.

Skeptics of the amyloid hypothesis have used the mismatch between pathological and clinical states as evidence against amyloid being the primary pathologic entity.

The conundrum is that we use transgenic animal models based on the amyloid hypothesis to test compounds for efficacy, and subsequently we exclude the patients whose pathomechanism is closest to the model organism, in which it is most likely that the observed effect is replicated.

The amyloid hypothesis is still used to explain the pathogenesis of Alzheimer's disease.

At this juncture, the only reasonable way forward is to test the "amyloid hypothesis" in human clinical trials using drugs and strategies that prevent amyloid from ever forming.

It is notable that each of these are unrelated to the amyloid hypothesis and were not tested in transgenic AD mice before being used in the clinic [ 66].

Further evidence for the amyloid hypothesis comes from Iceland.

Richard Scheller, of Genentech, believes that the Colombia study is probably the most scientifically direct test of the amyloid hypothesis.

Whether certain mutations accelerated the disease or slowed it down, "they all point to the amyloid hypothesis," he said.