5 We have also performed the entire analysis using the alternative approach of the principal factors and found the same qualitative results.
Analysis using the alternative classification scheme confirmed all the trends that we identified (Table S3F).
We have, however, conducted a robustness check by replicating the multiple regression analysis using the alternative binary and ordered probit specifications.
Under the stage 1 analysis using the alternative model assumptions where post-vicariance migration (M2) was 0.0 under the soft vicariance model, estimates of Z and E2) were respectively 3.64 and 0.66 (95% credibility intervals 0.00 – 9.74 and 0.35 – 0.35).
This analysis is also in need of more statistical power than the alternative analysis using change in responses across the whole scale.
SIG, however, was not associated with increased levels of MCP1 in our GLM analysis but was apparent in the alternative analysis using MARS.
In the alternative analysis using average accelerometer counts/minute as the criterion, correlations were slightly higher for both women (ρ = 0.33, 95% CI: 0.28, 0.38) and men (ρ = 0.25, 95% CI: 0.20, 0.31).
To overcome this, we used the alternative approach of autocorrelation analysis [ 26], in which correlations are determined between the complete gene set and matching sets shifted by gradually increasing distances along the genome.
Thus, in the present study, we have shown that the claimed association in Norway [ 3] is contradicted when using an alternative analysis and including data from all Nordic countries.
Using an alternative analysis strategy to more broadly characterize arsenic-associated expression modification, we used EVA software to graphically characterize functions of the top ranked 12,484 genes selected by ReliefF algorithm.
