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In addition to three markers detected using the additive model, six markers were deemed associated with an imprinting effect when the phenomenon was accounted for; the directions of the imprinting effects of all six markers were consistent with previously reported studies.
When using the additive model, it is removed by minus, that is to say H t) − X t) is the series to be decomposed in the next step.
Figure 9 Additivity mismatch for Toulouse, defined as excess in total expected distortion (using the additive model) over the simulated overall distortion (true value), as a function of BER.
There was no significant SNP×SNP interaction effect examined as either a two-way or three-way interaction using the additive model.
There was no evidence of a cumulative effect of carrying risk alleles in multiple SNPs, nor was there any evidence of a two- or three-way interaction effect of the SNPs using the additive model (data not shown).
These maps differed slightly from the relative risk map produced using the additive model as the relative risk in the additive model was more closely restricted to the areas of high population density.
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A practical drawback of using the additive models is that the current standard procedure for fitting additive models is still limited, whereas statistical software for the multiplicative model is available and easy to use.
The possibility of linking SFE to the parachor and the additive effects of the polar and dispersive components of SFE as provided in the Owens and Wendt theory [ 13], all that made us use the additive model as a tool to describe the effects of polyurethane chemical structures on the SFE values of the polymer films.
The default in FBAT was to use the additive model as several studies have shown that the additive model performs well even when the true genetic model is not additive 34.
The evaluation of the association between rs1344706 and the heterogeneity test is shown in Table 2. Since the genetic polymorphism model of ZNF804A is unclear, we used the additive model (A allele vs. C allele) for analysis.
This model was selected a priori and based on the reports from all previous prospective studies [ 12, 14, 15, 17], although we acknowledge that some previous cross-sectional studies have also used the additive model in their analyses [ 5].
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