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Using the Design library in S-PLUS software (version 8.0, 2007.
Statistical analyses were performed in R Statistical Software version 2.7.2 using the Design library (R Foundation for Statistical Computation, Vienna, Austria).
Because prediction models commonly show overly optimistic performance (i.e., overfitting) the c-index was computed with bootstrap sampling using the Design library in S-PLUS.
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The genomic DNA was sonicated (Covaris), ligated to methylated adapters and hybrid-selected using the designed custom 0.5-2.9 0.5-2.9Select bait library (Covaris).
The graphical presentation of a functional form of an association between Lden/NOx and diabetes was produced using restricted cubic spline in the design library (R 2.13.1 statistical software; http://cran.r-project.org/bin/windows/base/old/2.13.1/).org/bin/windows/base/old/2.13.1/
The graphical presentation of a functional form of an association between NO2 and confirmed diabetes was produced using restricted cubic spline in the design library (R 2.9.0 statistical software).
We used the function to estimate the first logistic regression model, while we used the and functions from the Design library (version 2.3-0) to estimate the logistic regression model that incorporated restricted cubic smoothing splines.
Another R function can be used like lrm (Hmisc library using the library Design) which is more restricted at present in the choice of the link functions.
Computational molecular design was applied to target the HIV-1 protease active site using a design library consisting of a scaffold with three variable positions.
We tested the linearity of continuous variables with restricted cubic splines using the Hmisc and Design library in R statistical software (R).
Calculations were performed with SAS version 6.12 and S-plus version 4.5 software, using the Hmisc and Design library (Harrell, 1997).
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