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Design the TALEN effector binding elements (EBEs) using standard principles applied in your laboratory.
Models will be constructed using standard principles; first univariable analyses will be used to identify variables significant at the p < 0.15 level and these variables then entered into multivariable models one-by-one, in decreasing order of significance.
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In practice this means that adverse effects from RCTs, case reports, case series, cohorts, and case controls cannot all be pooled together using standard meta-analysis principles.
Results are available in as little as an hour, compared with four or five days using standard methods.Having established the principle with head-and-neck cancer, the team hopes to extend it.
Results are available in as little as an hour, compared with four or five days using standard methods.Having established the principle with head-and-neck cancer, the team are now trying to extend it.
Also, unlike supertrees, they do not suffer from data independence or "signal enhancement" problems, and, at least in principle, confidence can be assessed using standard bootstrapping approaches.
Trial analysis was undertaken using standard methods for two-group comparisons for continuous, binary and time-to-event outcomes using intention to treat principles.
While, in principle, step 3 may be omitted for MCR-ALS, predictive accuracy proved to be superior when using standard spectra as a means to calibrate the model.
"The therapy I do really just uses standard, normal therapeutic principles," he said.
His spokesman told BBC News: "We agree with the principle of using standards to drive products that use less energy.
Household assets proxied for wealth based on a wealth index constructed using a standard principle components analysis of assets [ 56] and then grouped households into relative wealth tertiles, acknowledging that most TB households are not wealthy compared to India's general population [ 57].
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