Sentence examples for using small compounds of from inspiring English sources

Fragment screening is an alternative method to conventional high-throughput screening using small compounds of ~250 Da, which have many more desirable properties for the discovery of lead compounds than ~350 Da compounds used in conventional screening libraries.

Thus, restoration of p53 function to mutant p53 using small compounds has been extensively studied for cancer therapy.

In the examples of SLM applications presented in this chapter, the possibility to separate high quantities of compounds using small volumes of organic phases shows that this method is still a very attractive choice when an efficient and selective method is necessary.

This problem can be solved by using small quantities of specific surfactants to increase the compounds' bioavailability.

Finally, in vitro systems offer the advantage of rapid screening using smaller amounts of material such as compounds for pharmaceutical screening.

Use small quantities of joint compound in a mud pan or mortar board to prevent drying the entire bucket.

Use small amounts of paint.

On the rim stands a small compound of buildings.

172 High-throughput screening (HTS) methods have been used to discover small compounds capable of inhibiting PPI, especially when no structural information is available about the target proteins.

Although caution is required in the interpretation of experiments relying on the use of a small compound inhibitor of only modest potency (raising the possibility of off-target effects), our data also suggest that—similar to the situation with HIV Gag even partial inhibition of MSP processing may impact on invasion efficiency.

The low affinity of halogenated pseudilins for myosin-6 observed in these studies in combination with spatial constrains imposed by the allosteric pocket in myosin-6, guided us to the use of smaller compounds lacking either the phenyl or pyrrol moiety of the halogenated pseudilins.