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The total dose was increased thereafter to 45 Gy using single doses of 1.8 Gy.
Trials using single doses of ketamine <1 mg/kg report no changes in liver function tests [ 19].
These findings are in agreement with previous studies using single doses of radiation (1-5Gy) [ 16, 19].
Irradiation was delivered at room temperature using single doses of 240 kV X-rays (Isovolt 320/10; Seifert, Ahrensburg, Germany) filtered with 3 mm Be.
Irradiation was delivered at room temperature using single doses of 240 kV X-rays (Isovolt 320/10; Seifert, Germany) filtered with 3 mm Be.
Irradiation was delivered at room temperature using single doses of 200 kV X-rays (Yxlon Y.TU 320; Yxlon, Copenhagen, Denmark) filtered with 0.5 mm Cu.
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Most recent studies have used single doses of the following types of GnRHa: either triptorelin 0.2 mg [ 17], buserelin 0.5 mg [ 18], leuprolide acetate 1 mg [ 19], or leuprolide acetate 1.5 mg [ 20].
Although this was a small study which used single doses of rFVIIa that are lower than those recently shown to be both effective and well tolerated by adults and children with haemophilia with inhibitors, it highlights the importance of optimizing the dose regimen according to local resources and patient characteristics, such as age, with the possibility of reducing the cost of the treatment.
The results of our study are in concordance with these studies even though we enrolled children with mild exacerbations and used single dose of either medication delivered by MDI and spacer.
The 400 U/kg rHuEPO dose was chosen after performing dose-response experiments using single sc doses of 200, 400, 800, and 1,000 U/kg, in which the 400 U/kg dose produced the optimal capillary perfusion during sepsis (data not shown).
The optimal dose was determined in uninfected mice using single increasing doses of methacholine in different mice to choose the highest dose that gave little responsiveness.
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