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In this study, the mechanism of light-enhanced ketone reduction was investigated in detail using several inhibitors of photosynthetic electron transport and of enzymes of the Calvin cycle.
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Inhibition of proliferation by STI-571/Imatinib/Gleevec (Novartis, Basel, Switzerland) [ 27, 35] was determined using several different concentrations of inhibitor (from 0.1 μM to 2 μM) on an initial cell suspension of 5 × 103 cells/well of a 24-well plate.
We tested the applicability of the platform by conducting virtual screening of thrombin inhibitors using several screening strategies.
These results were further validated both in vitro and in vivo using gemcitabine, an inhibitor of RRM1 and RRM2, and UCN-01 and AZD 7762, inhibitors of CHK1, using several human triple negative cell lines and the C3(1)/Tag transgenic model of TNBC.
The general applicability of the seamless in silico modeling workflow is demonstrated using several datasets reported for small molecule inhibitors of renin.
To determine the cellular mechanism through which B-holo-Lf is taken up and internalized by both variants of amoebae, we used several types of inhibitors of endocytosis pathways, and B-holo-Lf internalization was evaluated by flow cytometry).
To investigate the signalling pathway that is involved in the removal of active caspase-3, we used several pharmacological inhibitors.
To investigate the role of MMP14 in gliomagenesis, we used several chemical inhibitors which affect MMP14 expression.
Several inhibitors of human GLOI showed that they are weak inhibitors of L. donovani growth.
Myelin debris contains several inhibitors of axonal regeneration [19].
Several inhibitors of PAR1 have been developed.
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