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The current study was conducted in previously untreated Chinese patients with advanced gastric adenocarcinoma using reduced doses of DCF.
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Souhami et al (1997) used reduced dose of cisplatin (60 mg m−2 IV on day 1) and Murray et al (1998) used a single course of a split cisplatin dose in their studies.
PURPOSE: The purpose of this study was to investigate the relationship between socioeconomic status (SES) and the use of intentionally reduced doses of chemotherapy in the adjuvant treatment of breast cancer.
Reduced doses of 1 to 2 mg could be used in future studies.
In contrast, due to direct targeting of the antigen to the dense network of skin dendritic cells through the MN delivery system, our results show that only one inoculation using a significantly reduced dose of nanoencapsulated antigen induces efficient prophylactic antitumor immunity through the activation of tumor-specific killing effector CD8+ cells.
As well as treating rejection early, doctors could use the test to reduce doses of immune-suppressing drugs for patients whose bodies are handling their transplanted organs well, thus reducing unnecessary drug side effects.
The largest trial of steroids in TBM used a reducing dose of dexamethasone, initially given intravenously at a dose of 0.3 to 0.4 mg/kg/day (depending on the severity of the meningitis) for a total of 6 to 8 weeks [ 65]; British guidelines suggest prednisolone (or equivalent) 20to4040 mg/day with gradual withdrawal.
Consideration should be given to reduced dosing intervals or the use of continuous infusions guided by appropriate monitoring, to ensure therapeutic plasma levels.
Norepinephrine is associated with a decreased rate of high-yield procurement and it seems clinically relevant to reduce doses or use of norepinephrine in brain-dead donors to increase the rate of organ procurement.
In parallel with using non-drug strategies, participants often self-managed asthma medication, aiming to reduce doses or frequency of use when possible.
Standard and reduced dosing permitted a maximum brainstem dose of 45 Gy and 25 Gy, respectively, each with a prescription dose of 60 Gy.
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