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We also examined whether inhibition of PDK1 can be a therapeutic modality by using reagents that target aerobic glycolysis or inhibit PDK1 mRNA.
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The question of whether Cbp80 has an independent role is experimentally important since the function of CBC is often inferred from using reagents that only target Cbp80 expression or interactions.
Another potential strategy for shifting Kupffer cell polarization is the use of therapeutic reagents that target epigenetic modifiers because epigenetic processes play central roles in the regulation of immune-system functions.
These data suggest that, in addition to allosteric modulators, reagents that target the kinase active site can also be assessed using the combination of C reductive lysine methylation and NMR spectroscopy described here.
In June, Lafayette, Colorado-based Dharmacon Inc. signed on with Exelixis Inc. in South San Francisco, California, to produce siRNA reagents that target 600 popular drug target candidates, including kinases.
The development of imaging reagents that target azides is an important next step.
RNAi reagents that target the same gene do not always yield consistent results.
RNAi reagents that target the same gene do not always yield consistent results due to false positives and weak or ineffective reagents.
The acetoin productivity was 10-fold higher than that obtained using reagent-grade sugars.
Morpholino is the most widely used reagent to knock down target gene expression post-transcriptionally.
Our findings confirm that the postoperative bleeding rates under continued anticoagulation therapy vary depending on the target of the therapy and the used reagents [ 20– 20].
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