Sentence examples for using parallel synthesis from inspiring English sources

Further optimization using parallel synthesis provided compounds with Ki's <50 nM.

Optimization of both ends of the lead molecule to improve potency, using parallel synthesis and iterative design, is described.

Using parallel synthesis supported by structure-based drug design, we identified peptidemimetic FVIIa/TF inhibitors (compounds 4 11) containing l-Gln or l-Met as the P2 moiety.

Using parallel synthesis supported by structure-based design and X-ray crystallography, we were able to identify a novel series of amidinophenylurea derivatives with remarkable affinity for factor VIIa.

All libraries were synthesized using parallel synthesis in a maximum of six steps.

Shortly, peptides were synthesized on cellulose membranes using parallel SPOT synthesis [ 17].

An 11-membered amide library (2 12) was subsequently generated using parallel solution-phase synthesis and Ghosez's reagent.

This report describes the synthesis, using parallel solution-phase methods, of a library of 104 potential inhibitors of PTPases.

In continuation of this effort, we now report a facile synthesis of a novel uridine analog library derived from amine 2 and carboxylic acid intermediates 33 and 77 (Schemes 1 and 2) using parallel solution phase chemistry.

Follow-up optimization using a parallel synthesis provided potent, single digit nanomolar antagonists.

Using a parallel synthesis approach, the potency and ADME properties of the mimetics were optimized in iterative cycles, resulting in the CXCR4 inhibitors POL2438 and POL3026.