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Using originator-brand medication resulted in much higher spending in the only diabetes study that used random sampling rather than convenience samples.
Average cost per patient for responders is €2.8877, using originators (darbepoetin α, epoetin α and epoetin β) for the 15-week ESAs treatment (6-cycles chemotherapy) and €5.0199 in the case of non-responders.
The goserelin pharmacokinetic/pharmacodynamic (PK/PD) relationship (measured using the originator Zoladex®) is nonlinear (on-off response) and time-dependent due to the de-sensitization of the pituitary gland which is maintained with very low levels of goserelin once achieved.
Several mechanisms have been used by originator companies to allow access to ARVs in low-income settings.
In addition, a cryptographic hash of each message would be encrypted by the message originator using its private key, and this electronic signature would be decrypted by each recipient using the public key of the message originator and verified against the actual message.
Hyperbolic position bounding (HPB) provides a mechanism to probabilistically estimate the candidate location of an attack message's originator using received signal strength (RSS) reports, without assuming knowledge of the transmitting power.
Medical or substantive data is encrypted by the originator using a key shared with the second database.
The objective of this paper is to elaborate epidemiological, clinical and economic data on ESAs consumption in Greece, in order to determine potential cost savings by using biosimilar over originator ESAs under different dosing schemes for the management of the newly diagnosed chemotherapy-induced anemic patients.
The possibility to use several originators increases the flexibility of approach by covering a broader class of network topologies and allows a recursive modeling.
Originators using Blackmoon maintain a relationship with borrowers while offloading credit risk.
This article aims to define a value-based approach to pricing and reimbursement for off-patent originators using a multiple criteria decision analysis (MCDA) approach centered on a systematic analysis of current pricing and reimbursement policies in China.
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