Exact(3)
The combination treatments using chemotherapeutic agents with distinct molecular mechanisms are considered more promising for higher efficacy; however, using multiple agents contributes to added toxicity.
It has also been reported that targeting both pathways simultaneously can be advantageous in treating glioblastoma neurospheres, but this is difficult to achieve in vivo using multiple agents.
The rationale for combination therapy is based on the view that resistance to any single agent in a heterogeneous tumour cell population could be overcome by using multiple agents with different mechanisms of action.
Similar(57)
The authors of [38] propose a system which is based on J2EE and also uses multiple agents in combination with an ontology.
An alternative approach is to use multiple agents, with known activity, at full dose, but with a short intercycle time interval to prevent tumour recovery between treatments.
First, the "sandwich RNA-inhibition strategy" uses multiple agents to focus on a major molecular alteration that is clearly linked to CLL pathogenesis.
Such observations help us to understand why type 2 diabetes, a relentless progressive disease, requires advances from monotherapy with oral antidiabetic agents to combination therapy using multiple oral agents and finally insulin replacement without undue delay (34).
A task that requires specific equipment would require unique agents; Merino et al. [ 13] looked at using multiple heterogeneous agents for cooperative fire detection.
The standard of care for treatment-naïve aggressive ATL (acute-, lymphoma- and unfavorable chronic-type) has been aggressive chemotherapy using multiple cytotoxic agents as well as combination of interferon-α with anti-retroviral agents outside Japan.
4 A standard salvage treatment has not yet been established except single agent mogamulizumab by prospective clinical trials, 5 and thereby chemotherapy using multiple cytotoxic agents not contained in prior treatments has been used in practice.
Olivine (LiCo1/3Mn1/3Ni1/3PO4) powders were synthesized at 550 600 °C for 6 h in air by a sol gel method using multiple chelating agents and used as a cathode material for rechargeable batteries.
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