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Furthermore, these studies show that optimizing microarray scanning conditions allows for the identification of significant disease-associated alterations in gene expression using minimal numbers of mice.
Our study included analysis of scrapie strain 22L which has not previously been reported in gene expression profiling studies, and implemented refined microarray analysis methodologies that allowed for identification of significant disease-associated alterations in gene expression using minimal numbers of mice.
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This method can be used to satisfy not only traditional design objectives like product yield and growth but can also incorporate more complex design objectives like high growth-coupled product yield using minimal number of knockouts or even non-linear objectives.
The fabrication process uses minimal number of layers and masks to reduce the fabrication cost.
Due to limited number of data points that was extracted from test samples it was necessary to use minimal number of components in GMM to prevent overfitting.
We emphasize here that despite our approach to use minimal number of tests by testing only those effects with significant effect on variance as shown by F-tests, multiple hypothesis tests are conducted and this increases the possibility that the some of the outcomes may be due chance.
Compartment models, as implemented in NONMEM, provide an unbiased parametric description of a data set using a using a minimal number of model assumptions.
These FCM-based techniques use only minimal numbers of primary B cells, and eliminate the need for FACS-based cell sorting of individual B cell populations.
PCR amplicon libraries were prepared using a minimal number of amplification cycles (25 cycles) to minimize the accumulation of PCR artifacts.
By using this method of comparison, a number of biomaterial constructs may be compared under similar conditions and the optimal construct elucidated using the minimal number of animals and materials.
Here, we develop and validate an automated extraction process using magnetic silica bead technology suitable for the serial extraction of DNA and RNA from many different types of solid tissues using a minimal number of reagents [ 5].
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