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The biosensor imaging capability is expected to yield applications in pharmaceutical compound screening, genomics, proteomics, and molecular diagnostics, where there is a need to screen large numbers of biochemical interactions against samples using low volumes of reagents.
In the 1940s a new breed of herbicide was born that allowed for relatively low amount of chemical applied, using low volumes of water, meaning that we could selectively kill the weed without harming the crop plant.
Previous work has shown adequate tagging may be achieved using low volumes of 40% w/v barium, although the ideal volume and dosing regimen has not been fully established [ 9].
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Hereafter this method using low volume of culture media was called the micro-ALS method.
Utilizing a combination of physics, chemistry, biology, and biotechnology, along with practical applications for designing devices that use low volumes of fluids to achieve high-throughput screening, is a major goal in microfluidics.
The method under investigation used low volume of solvent (5 mL), low sample mass (1.5 g) and low mass of chitin (0.5 g), an environmentally friendly support.
Fruit flies that are very important pests on a large number of crops, can be controlled efficiently using low-volume applications to deposit large droplets of insecticidal bait on the exterior of the crop canopy.
Indeed, it is well established that mortality of patients with acute respiratory distress syndrome (ARDS) is lower using low tidal volumes approximating 6 ml/kg of predicted body weight [38].
In the general intensive therapy unit, the incidence of ventilator-associated lung injury has been reduced following introduction of lung-protective ventilator strategies using low tidal volumes and permitting a degree of hypercapnia [ 38].
Present strategies at minimising VILI in critically ill patients consist of using low tidal volumes (VT) [ 1].
The prevention of respiratory failure can reduce ICU LOS by 43% (-4.9 days; 6.6 days instead of 11.5 days), which could be supported by lung protective ventilation using low tidal volumes or the use of positive end expiratory pressure ventilation, among other strategies [ 40].
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