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About the same time, researchers at the University of Toronto, inspired by discussions with Dr. Folkman, were doing similar studies in mice, using low doses of a chemotherapy drug, vinblastine, combined with an experimental drug that fights angiogenesis, DC101.
The potential of using low doses of aromatase inhibitors to lower "in breast" estrogen levels without unduly perturbing plasma concentrations is also being explored.
Dr Louise Bowman, one of the researchers, said: "It may be safer to lower cholesterol using low doses of the more potent statins rather than increasing the dose of simvastatin".
The researchers are proceeding carefully in human trials and using low doses of the drugs, because animal experiments have shown that overactivation of excitatory glutamate receptors with ampakines can lead to seizures.
Despite the above microstructural limitations, it was found that using low doses of sodium oleate (0.25% w/w) the mortars accomplished the highest performance in terms of capillary water absorption and mechanical strength.
In clinical practice, in Europe physicians are still using low doses of aminoglycosides, as shown by a recent survey of antimicrobial prescribing practices in ICUs, where aminoglycosides were administered at "low" doses (5 mg/kg for gentamicin and 15 mg/kg for amikacin) [27].
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Experiments are ongoing trying to use low doses of MDMA during therapy sessions to help people with post-traumatic stress disorder talk about their trauma in an environment that doesn't trigger their panic.
In two randomized and double blind placebo controlled experiments, we used low doses of lipopolysaccharide (LPS) as an experimental model of systemic inflammation.
For more than 40 years, livestock producers have used low doses of antibiotics to fatten healthy livestock, presumably by easing minor infections that don't make animals overtly sick.
Because we used low doses of LT without influencing the MEK1 of splenic and peripheral blood mononuclear cells (Fig. 4A, 50 µg/kg LT groups), the MEK-dependent suppression on bactericidal superoxide [12] is not likely to be involved.
We used low doses of WGA that have, individually, proven safe in humans.
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