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It is possible that using larger doses of heparin may result in a better control of bleeding.
In the phase I study using larger doses of sorafenib, 600 and 800 mg twice daily, skin rash, hand foot syndrome, diarrhea, nausea, hypertension, and fatigue were observed as the most common adverse events.
On the other hand, the FDA has just advised against using larger doses of quinine, found in the drug Qualaquin, to treat muscle cramps.
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Central banks have been using large doses of experimental drugs, and nobody knows for sure whether there will be hazardous side-effects.
By Miami, where Cuban-Americans are an influential voting bloc, Mr. Bush and his brother were using large doses of Spanish in their speeches.
Because of this significant correlation, we decided to investigate the metabolism of tyramine in normal and dietary migraine subjects using large doses of tyramine and, separately, tracer doses of 14C-tyramine.
Recent reviews have raised concerns about the safety of using large doses of β2-agonists, especially in patients with underlying cardiovascular comorbidity.
Recent reviews have raised concerns about the safety of using large doses of β2-agonists, especially in patients with underlying cardiovascular comorbidity [27 29].
Instead of using large doses of pharmacological agents to inhibit or suppress symptoms, very small and specially prepared doses of medicinal substances are individually prescribed to a person for their unique ability to cause in overdose the similar symptoms that the sick person is having.
The dosing is adjusted according to the clinical response of the patient, but large doses may be needed in severe cases (there is a risk of precipitating metabolic acidosis due to the preservative propylene glycol when using large doses of diazepam).
Bierman and colleagues used larger doses of D-ribose given to patients with both mild and severe diabetes and confirmed Segal's finding (Bierman et al., 1959).
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