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Therefore, additional studies using large cohorts of patients and more stringent response criteria are necessary.
Finally, no long-term studies using large cohorts of LN patients have been performed.
Many of the component measurements are subjective, imprecise and insensitive to change and their use often necessitates lengthy and costly clinical trials using large cohorts of patients.
These platforms need to include more relevant peptides and these platforms should be validated by using large cohorts of healthy controls, patients with RA and disease controls.
The first studies characterizing DNA methylation at a genome-wide scale and using large cohorts of patients to investigate prognostic signatures were performed on hematopoietic malignancies.
Further studies using large cohorts of negative and positive individuals from endemic areas are still required to determine the use of these antigens (alone or in combination with different recombinant proteins) for control of CVL in endemic areas.
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This was likely due to limited sample sizes, and indicates that additional comparative studies are warranted using larger cohorts of g/g and g/a polymorphic subjects to confirm metabolite differences observed herein.
Further studies using larger cohorts of Malay individuals are needed to address these possibilities.
these were underpowered, however, and further studies using larger cohorts of mothers and babies are needed to replicate these results.
Further studies using larger cohorts of ICU shock patients should elucidate the diagnostic and prognostic role of natriuretic peptides in this complex patient population.
However, further work is needed to evaluate the prognostic and/or predictive value of these biomarkers in prospective studies using larger cohorts of patients.
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