The current environmental detection method using laboratory mice is expensive and time-consuming, and although there is ongoing research into more rapid detection techniques (e.g., using polymerase chain reaction analysis to detect the fungus in soil samples), it will be several years before time series of such data become available.
Scientists put the folk wisdom to the test using laboratory mice with bacterial and viral infections.
Assessment of cytotoxicity of natural products is normally determined by either cell culture methods employing specific cell lines or using laboratory mice as experimental animals.
In addition, results of several early studies were questionable because EMCV was isolated by using laboratory mice; researchers could not unequivocally establish that the virus did not originate from the mice used for isolation and passage rather than from human clinical specimens (12 ).
Further examples can be found in Kim et al. [ 5] and Pérez-Enciso et al. [ 6], both using pig crosses, or in Li et al. [ 7] using laboratory mouse populations.
Here, we use laboratory mice to analyze, first, to what extent human and chimpanzee diets induce differences in gene expression, and, second, whether such differences may be similar to gene expression differences seen between humans and chimpanzees.
Because commonly used laboratory mice are known to have originated from a limited founder population in a few laboratories [13], [14], new genetic variants affecting circadian rhythms, which we cannot find in commonly used laboratory mice, might be obtained from wild mouse population.
It has been reported that freezing is not observed in commonly used laboratory mice but occurs frequently in wild mice (Blanchard et al. 1998; Fernandes et al. 2004; Holmes et al. 2000), and thus B6-ChrNMSM consomic panel mice were expected to be an interesting tool to identify genetic loci associated with 'wildness'-related phenotypes.
The team used laboratory mouse models of nerve injuries to simulate pain symptoms commonly associated with post-surgical nerve trauma.
Male Kunming mice (8-weeks old, 38.50±1.51 g), a widely used laboratory mouse strain in China, were obtained from the Laboratory Animal Center at Shantou University Medical College.
