In response to reviewer 1 we re-did the proteomics using a different approach and there was still no evidence for PRC1 components in either analysis.
The other statistics should also be re-done using this approach.
We've been using this time to re-examine what we do here, and to figure out how we can be more efficient.
In the revision, we re-did differential analysis using the "per-condition" method and updated all related results accordingly (Tables 1, 2, Figure 2 figure supplement 1-4, Figures 3A, B, and motif analysis, Figure 4 figure supplement 3).
Some of the settlement money can be used to re-create what nature would normally be doing by placing controlled gates and channels along the river that will be opened periodically to allow sediment--basically food-rich mud--that flows down the Mississippi to replenish wetlands.
[Be aware that spyware/viruses "do" use restore points to re-install themselves after the next reboot.
If you take apart some pipe to replace it or to re-thread the connection, do not use the Teflon that is already on the pipe.
Using sample size re-estimation does not have this issue, but it is sensitive to the values used in the conditional power formula.
Rather than using restrictive enzyme (RE) as done in conventional Hi-C, which generates predictable and consistent fragment ends, DNase I produces a heterogeneous mixture of fragment ends that greatly improves the efficiency and resolution.
Adjusting the drug resistance proportions using the re-testing results did not change the estimated national mean prevalence significantly.
