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A very good text editor that can be installed on both a Windows machine and on a linux-based machine (Mac, Ubuntu, etc). is Sublime Text, which is what we will be using in this tutorial.
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The methods used in this tutorial avoid the use of approximations, instead utilising cumulative count statistics directly in the analysis.
The data used in this tutorial was collected from a study supported by the Wellcome Trust Trilateral Initiative for Infectious Diseases (Grant No.: 063144).
Therefore, in the future the latest versions of the packages used in this tutorial may not be backward compatible with the code presented here.
The PK data set used in this tutorial (pktab1) is available in the Supplementary Table S1 online and contains plasma concentration data obtained from a simulated clinical trial of a novel i.v. drug, performed in 50 patients, measured at 8 time points.
(Note: The #2 sticker on the phone used in this tutorial fell off).
A NYX jumbo pencil in Milk is used in this tutorial.
The one used in the tutorial is GIMP.
Teaching and learning methodologies used in this curriculum include PBL tutorials and seminars; practical sessions including anatomy dissections, laboratory work and simulations; structured clinical skills training; lectures; and community field work.
A total of four web-based tutorials were used in this study.
In short, the data was organized as m × n matrix where m is the different samples (columns) and n is gene set Z-values (rows), mean of each row was subtracted and SVD was calculated using JMP's in-built SVD function as illustrated in this document: http://www.cs.princeton.edu/picasso/mats/PCA-Tutorial-Intuition_jp.pdf and also used in this script: http://abs.cit.nih.gov/MSCLtoolbox.nih.gov/MSCLtoolbox
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com