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The results of this study warrant a larger randomized placebo controlled trial using higher doses of ketamine and a longer follow-up period.
These data indicate a slight clinical improvement in the questionnaire results that needs to be studied further using higher doses of PEA.
As our primary hypothesis was that passive mobilization would potentially cause a worsening in the microcirculation we also hypothesize that this would occur mainly in patients using higher doses of noradrenaline.
In initial experiments using higher doses of bacteria, ranging from 4.5×106 to 8×106 bacteria per mouse, infection with the sigS mutant gave rise to significantly less mortality when compared to animals infected with SH1000 (Fig. 6A).
Using CD1d-transfected Hela cells and dendritic cells as APCs, this pattern could be induced by using either suboptimal doses (<1 nM) of strong agonists such as KRN7000 or the C20 2 analog, or by using higher doses of weak agonists with N-aromatic branching (∼100 nM).
Additionally, using higher doses of a probiotic cocktail might prove effective [ 56].
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The revised Figure 7 only included the data of short-term effects of MEKi treatment and added new data using higher dose of MEKi in Figure 7F.
Our results support using higher dose of daptomycin for difficult-to-treat infections caused by resistant pathogens, compatible with other reports [ 13- 17].
Using high doses of cocaine triggers brain cells to eat themselves, new research has found.
However, strategies to induce durable tolerance using high doses of soluble antigen have to date been unsuccessful, due to lack of efficacy and the risk of hypersensitivity.
It is important to monitor patients for bradycardia, especially when using high doses of dexmedetomidine.
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