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Using high doses of cocaine triggers brain cells to eat themselves, new research has found.
However, strategies to induce durable tolerance using high doses of soluble antigen have to date been unsuccessful, due to lack of efficacy and the risk of hypersensitivity.
No changes in absolute serotonin or dopamine concentrations have been reported with either acute or chronic treatment using high doses of PCP suggesting that there are no neurochemical lesions of these two important neurotransmitter innervations likely to be involved in the rewarding/dysphoric actions of PCP (Jentsch et al, 1997b; Noda et al, 2000; Balla et al, 2001).
It is important to monitor patients for bradycardia, especially when using high doses of dexmedetomidine.
Besides the natural factors, certain anthropogenic sources which contribute to fluoride in groundwater are mainly the agriculture industry using high doses of phosphatic fertilizers, clay industries and industries using coal, for e.g., thermal power plants and brick kilns.
Current recommendations are based on these later trials, favouring a high peak serum concentration using high doses of aminoglycoside as boluses and close monitoring of residual serum concentrations to avoid renal toxicity.
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To study the effect of gastroesophageal reflux disease (GERD) management by using high dose of proton pump inhibitors (PPIs) on the outcome of uncontrolled asthma.
Adult zebrafish were sacrificed by euthanasia using high dose of MS222, brains were dissected immediately and fixed overnight in 3% paraformaldehyde.
Promising results were achieved using high dose of aspirin to inhibit growth of sarcoma cells cultures among mice [ 15].
Light microscopic examination of renal tissue revealed normal histology (data not shown) similar to the findings of others using high dose of LPS [ 38, 39].
The results of this study warrant a larger randomized placebo controlled trial using higher doses of ketamine and a longer follow-up period.
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