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Although using high dosage of alcohol was particularly useful for obtaining a higher conversion yield for the antioxidant (hexyl dihydrocaffeate) but its separation and purification from the residual unreacted alcohol in solutions containing the DHCA/hexanol mole ratio greater than 1 2 posed serious problems.
However, to our knowledge, previous studies demonstrated ability to reduce postoperative blood loss with a variety of techniques and mostly using high dosage of tranexamic acid (TXA) (500-3,000 mg) [ 6, 7, 10- 12], while our previous study also showed benefit of blood loss and transfusion reduction in computer-assisted surgery TKR with combined low-dose TXA (250 mg) with 2-hour clamp drain [ 9].
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15 Although FAS might reduce the risk of several harmful pregnancy outcomes and childhood problems, many questions still remain open on the potential effects of using high dosages of FAS at different periods during pregnancy.
Other study that used soybean isoflavone to reduce AV lesion had never been performed yet, but several studies had proved the advantage of isoflavone of 160-mg dosage, such as study that used high dosage of isoflavone (160 mgs) for 12 weeks in menopause women, here had occured a decrease in the expression of inflammation mediator.
We hypothesise that a higher dosage increment or a longer duration of oxytocin may be required in diabetic labours to counteract the inherent poor uterine contractility, although any adverse outcomes of using higher dosages of oxytocin would need to be considered.
At discharge in September 2008 she was bedbound and used high dosages of corticosteroids.
We also found that nearly one-third of the women used high dosages of FAS (≥1000 µg/day).
It is recommended to use high dosages of benzodiazepines and to perform electroconvulsive therapy in case of resistance or a life threatening condition [ 15].
The used high dosages of TaCel7A (CBM+) and TaCel7A (CBM-) were 21.2 and 18.8, and those of TaCel5A (CBM+) and TaCel5A (CBM-) were 4.2 and 3.4 mg protein/g DM, respectively.
Trials that have used higher dosages of misoprostol, via the vaginal route, using the longest time interval between administration of misoprostol and hysteroscopy have tended to show more favourable outcomes regarding cervical ripening.
High-quality randomised placebo-controlled trials using higher dosages and taking into account the clinical heterogeneity of MOH are needed.
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